Mounjaro is a prescription injectable medicine whose active ingredient is tirzepatide.
It is not insulin. Instead, it works by stimulating the body’s own mechanisms to regulate blood sugar and affect metabolism.
Mechanism of action: Tirzepatide acts as a dual receptor agonist — it activates both the GIP (glucose-dependent insulinotropic polypeptide) receptor and the GLP-1 (glucagon-like peptide-1) receptor. This dual action helps improve insulin secretion when blood sugar is high, reduces the liver’s glucose output, slows gastric emptying (so you feel fuller for longer), and suppresses appetite.
🌟 Product Overview
✔️ Innovative Once-Weekly Injectable Therapy – Mounjaro Kwikpen is a ready-to-use, pre-filled injection designed to be administered once weekly under the skin (subcutaneously).
✔️ Convenient & Patient-Friendly – Each pen contains four pre-measured doses, eliminating complex dose preparation and minimizing patient burden.
✔️ Dual Hormonal Action – Tirzepatide acts as both a GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1) receptor agonist, offering a novel mechanism to improve metabolic health.
🧬 Mechanism of Action
🔹 Dual Incretin Receptor Activation:
Tirzepatide simultaneously stimulates GIP and GLP-1 receptors — two key incretin hormones involved in glucose regulation. This dual activation:
Enhances insulin secretion in response to elevated blood glucose
Reduces glucagon release, lowering hepatic glucose output
Slows gastric emptying, increasing feelings of fullness
Influences appetite-regulating brain centres, supporting weight loss
This combined action leads to effective glycaemic control and appetite suppression, supporting both diabetes management and weight loss goals when used as prescribed.
🎯 Indications & Therapeutic Use
📌 Primary Uses:
✔️ Type 2 Diabetes Mellitus Management:
Improves glycaemic control when diet and exercise alone are insufficient, particularly in adults with type 2 diabetes.
✔️ Chronic Weight Management:
Used as part of a comprehensive weight management plan in adults with obesity or overweight conditions, under physician supervision.
📍 Key Benefits
✨ Once-Weekly Convenience: Only one subcutaneous injection per week required — increasing adherence and simplifying treatment regimens.
✨ Metabolic Support: Improves blood sugar control by targeting underlying hormonal imbalances.
✨ Weight Loss Assistance: Slows digestion and reduces appetite, helping patients feel full longer.
✨ Low Dosing Flexibility: The 5 mg strength is part of a flexible dose range that allows healthcare professionals to personalise therapy.
📋 Dosage & Administration
➡️ Route: Subcutaneous
➡️ Frequency: Once weekly
➡️ Injection Sites: Abdomen, thigh, or upper arm (rotate sites each week)
➡️ Timing: Administer on the same day each week, with or without food
Important: Always follow the dosing instructions provided by a healthcare professional. Do NOT exceed the prescribed dose.
⚠️ Safety & Precautions
🚫 Contraindications:
Personal/family history of Medullary Thyroid Carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome Type 2
Known allergy to tirzepatide or pen components
⚠️ Use With Caution In:
Patients with severe liver or kidney disease
History of pancreatitis
Individuals with diabetic retinopathy
Pregnant or nursing women (consult physician)
💡 Important: Not recommended for Type 1 diabetes or for cosmetic weight loss outside of medical guidance.
🚨 Common Side Effects
🟡 Most frequent adverse reactions are gastrointestinal and tend to occur early in therapy:
Nausea
Vomiting
Diarrhoea
Constipation
Abdominal discomfort
Decreased appetite
☑️ These effects often diminish with continued use, but persistent or severe symptoms should prompt medical consultation.
❄️ Storage & Handling
📍 Storage Conditions:
2 °C – 8 °C (Refrigerate) — Protect from freezing and light.
🧊 On removal from refrigeration, the pen may be kept at room temperature for a limited period as advised by your healthcare professional.
📩 Disposal:
Discard the pen properly after delivering all prescribed doses per local medical waste guidelines.
🏷️ Summary of USP Features
✅ Dual-action incretin therapy
✅ Once-weekly, simple administration
✅ Supports glycaemic control & weight management
✅ Pre-measured and easy to use
✅ Flexible, clinician-guided dosing

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